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For cases outside of North or South America, China/Japan/Korea please visit our collaborators at The EASL

Dear Colleagues,

We are pleased to announce that, with the full endorsement of the AASLD, we have relaunched as SECURE-Liver ( Together with our collaborators at the EASL, we aim to assess outcomes of COVID-19 in patients with chronic liver disease and prior liver transplant including updated questions on the role of living conditions and employment, alcohol use, thromboembolic complications, novel COVID-19 therapies, emerging SARS-CoV-2 variants and post-vaccination infections.

We hope you will report cases of COVID-19 in chronic liver disease and post-liver transplant patients, regardless of severity of COVID-19 (including asymptomatic patients detected through public health screening). Reporting a case should take approximately 5 minutes. The success of this collaborative effort relies upon ongoing submissions and we thank all previous contributors, which culminated in several publications on COVID-19 outcomes in patients with chronic liver disease/cirrhosis, liver transplant recipients and autoimmune hepatitis.

Key points:

  1. Given that the registry is limited to de-identified data, the UNC-Chapel Hill Office for Human Research Ethics has determined that storage and analysis of de-identified data does not constitute human subjects research as defined under federal regulations [45 CFR 46.102 and 21 CFR 56.102] and does not require IRB approval. If your institution requires IRB approval for you to participate, visit our FAQ page for links to our case report form and NHSR letter from the UNC Office of Human Research Ethics.
  2. Every individual and center that submits at least one case will be acknowledged on our website and resulting publications. Major contributing centers will be invited to form part of the co-authorship on future publications.

We hope you will actively contribute to this AASLD-endorsed international effort. Through ongoing participation and collaboration, we hope to continue to answer these very pressing questions for our chronic liver disease and post-liver transplantation patients and their caregivers.

To report a case of coronavirus in a patient with chronic liver disease or prior liver transplant, click here.


If you have any questions, please reach out to

In addition to the reporting cases of COVID-19 to SECURE-Liver, we also encourage reporting to your local public health agency where applicable.



Andrew M. Moon, MD, MPH (Assistant Professor of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill)

A. Sidney Barritt IV, MD, MSCR (Professor of Medicine, Division of Gastroenterology and Hepatology, Director of Hepatology, University of North Carolina at Chapel Hill)